منابع مشابه
PReS13-SPK-1277: Role of ß2GPI in APS
b2-Glycoprotein I (b2-GPI), also known as apolipoprotein H, is a 50 kDa protein that was described for the first time in 1961, and in 1968 the first apparently healthy person was identified deficient in this protein. As no function could be attributed to b2-GPI, the protein did not receive much attention and on average a single publication per year appeared in the literature. From 1990 onwards,...
متن کاملPReS13-SPK-1240: New aspects on APS pathogenesis
Antiphospholipid antibodies (aPL) are both diagnostic markers for, and pathogenic drivers of, antiphospholipid syndrome (APS). Beta 2 glycoprotein I (Beta2GPI)dependent aPL, the most important subset, mediate different–and not necessarily alternative–thrombogenic mechanisms, mainly on the basis of their reactivity with Beta2GPI expressed on cells that participate in the coagulation cascade. In ...
متن کاملPReS13-SPK-1469: Juvenile scleroderma
Juvenile localized scleroderma, also known as morphea, is the more frequent subtype of scleroderma in childhood. It comprises a group of distinct conditions which involve the skin and subcutaneous tissues. They range from very small plaques of fibrosis involving only the skin, to diseases which may cause significant functional and cosmetic deformity. The most widely used classification divides ...
متن کاملPReS13-SPK-1127: Pediatric rheumatology in India
Pediatric Rheumatology took birth in India with the formation of an interest group of the Indian Academy of Pediatrics and the first conference in 2001 in Mumbai. Now 11 conferences old, it has about 200 members and 12 centers offering part time or whole time care. With a population of over 1000 million, it may be extrapolated from Western data that India should have at least 400000 children wi...
متن کاملPReS13-SPK-1129: Biologic therapies in SLE
Biologic therapy has not made the breakthrough in the treatment of patients with systemic lupus erythematosus (SLE) that it has managed in patients with rheumatoid arthritis and psoriatic arthritis. However, there are distinct signs that this form of treatment is going to find a place in the pantheon of SLE therapy. Based on a better knowledge of the ethiopathogenesis of lupus drugs, which inte...
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ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2013
ISSN: 1546-0096
DOI: 10.1186/1546-0096-11-s2-i12